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Opana ER is an extended-release opioid medication used for managing chronic and severe pain. It contains oxymorphone, a potent opioid analgesic that acts on the central nervous system to reduce pain signals. The extended-release formula is designed to provide steady pain relief over many hours. Due to its strength and high potential for dependence, misuse, and overdose, Opana ER is strictly controlled. In fact, certain formulations have been discontinued in the United States because of significant safety concerns.